EGFR/CDK2-IN-4

SKU: orb2277729

Description

EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, with IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It induces apoptosis and S phase cell cycle arrest in MCF-7 cells, showing significant anti-cancer activity with an IC50 of 2.74 μM against MCF-7 cells [1].

Research Area

,Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Key Properties

• MW: 468.55
• Purity: 98.00%
• Formula: C₂₄H₁₆N₆OS₂

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only