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Ensitrelvir

SKU: orb1297924

Description

Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM.

Research Area

Product Categories/Products/Small Molecules,Microbiology/Virology

Images & Validation

Key Properties

CAS Number2647530-73-0
MW531.88
Purity99.81%
FormulaC22H17ClF3N9O2
SMILESO=C1NC(=NC2=CC3=CN(N=C3C=C2Cl)C)N(C(=O)N1CC=4N=CN(N4)C)CC5=CC(F)=C(F)C=C5F

Bioactivity

Target IC50
3CLpro (SARS CoV-2):13 nM
In Vivo
Ensitrelvir inhibits intrapulmonary replication of SARS-CoV-2 in mice in a dose-dependent manner.
In Vitro
The EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information

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10 mg
$ 150.00
25 mg
$ 220.00
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