FGI-106 tetrahydrochloride

SKU: orb1309675

Description

FGI-106 tetrahydrochloride

Research Area

Product Categories/Products/Small Molecules,Proteases/Proteasome|||Microbiology/Virology

Key Properties

• CAS Number: 1149348-10-6
• MW: 604.48
• Purity: 98.98%
• Formula: C₂₈H₄₂Cl₄N₆
• SMILES: Cl.Cl.Cl.Cl.CN(C)CCCNc1cc(C)nc2c1ccc1c2ccc2c(NCCCN(C)C)cc(C)nc12

Bioactivity

• Target IC50:
  HCV: 200 nM |Rift Valley virus: 800 nM |HIV-1:150 nM |DENV: 400-900 nM |EBOV:（EC50）100 nM
• In Vivo:
  FGI-106 treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
• In Vitro:
  In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

44128993