Foretinib (GSK1363089,XL880)

SKU: orb181181

Description

Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

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Key Properties

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CAS Number	[849217-64-7]
MW	632.65
Formula	C₃₄H₃₄F₂N₄O₆
SMILES	O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O

Storage & Handling

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Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Chemical structure of Foretinib (GSK1363089,XL880)

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