Glycoprotein 2 Antibody / GP2 / ZAP75

SKU: orb1825359

Description

GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Images & Validation

• Tested Applications: ELISA, IHC-P, WB
• Dilution Range: ELISA: 2-4mg/ml for coating (order BSA-free format),Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG2c, kappa
• Clone No.: GP2/3510
• Immunogen: A recombinant fragment of human protein (within amino acids 35-179) was used as the immunogen for the Glycoprotein 2 antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the Glycoprotein 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Glycoprotein 2 antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P55259