GPR183 antagonist-2

SKU: orb2566165

Description

GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].

Key Properties

• CAS Number: 2924063-98-7
• MW: 432.38
• Purity: 98.00%
• Formula: C₂₀H₁₈F₂N₄O₅
• SMILES: C(=C/C(=O)N1CCN(C(=O)C=2C=NC(OC)=NC2)CC1)\C=3C=C4C(=CC3)OC(F)(F)O4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169494480