GSK4112

SKU: orb1302143

Description

GSK4112

Research Area

Product Categories/Products/Small Molecules,Autophagy

Key Properties

• CAS Number: 1216744-19-2
• MW: 396.89
• Purity: 99.69%
• Formula: C₁₈H₂₁ClN₂O₄S
• SMILES: CC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1

Bioactivity

• Target IC50:
  Rev-Erbα:0.4 μM(EC50)
• In Vitro:
  GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

50905018