GW-506033X(PKR Inhibitor C16)

SKU: orb746367

Description

C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [608512-97-6]
• MW: 268.294
• Formula: C₁₃H₈N₄OS
• SMILES: O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only