Halofuginone hydrochloride

SKU: orb2283776

Description

Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.

Research Area

,Others

Key Properties

• CAS Number: 1217623-74-9
• MW: 451.14
• Purity: 98.00%
• Formula: C₁₆H₁₈BrCl₂N₃O₃
• SMILES: Cl.OC1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

46781676