hCG Receptor / LH Receptor Antibody

SKU: orb1823928

Description

Recognizes a protein of 78-85kDa, which is identified as Luteinizing hormone / choriogonadotropin receptor. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG2, kappa
• Clone No.: LHCGR/7399
• Immunogen: A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the Luteinizing Hormone Receptor antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the Luteinizing Hormone Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Luteinizing Hormone Receptor antibody is available for research use only.
• Disclaimer: For research use only

IHC staining of FFPE human ovarian carcinoma tissue with Luteinizing Hormone Receptor antibody (clone LHCGR/7399). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

IHC staining of FFPE human testis tissue with Luteinizing Hormone Receptor antibody (clone LHCGR/7399). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free Luteinizing Hormone Receptor antibody (clone LHCGR/7399) as confirmation of integrity and purity.

Quick Database Links

UniProt

P22888