HDAC-IN-53

SKU: orb1982624

Description

HDAC-IN-53 is an orally active, selective inhibitor of HDAC1-3, with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. It exhibits no inhibitory effects on class II HDACs (HDAC4, 5, 6, 7, 9; IC50 > 10 μM). The compound induces caspase-dependent apoptosis and significantly hampers the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice with MC38 colon cancer [1].

Research Area

,Chromatin/Epigenetic|||DNA Damage/DNA Repair

Key Properties

• CAS Number: 2921948-27-6
• MW: 461.9
• Purity: 98.00%
• Formula: C₂₃H₂₀ClN₇O₂

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only