HSP70-IN-1

SKU: orb1304155

Description

HSP70-IN-1

Research Area

Product Categories/Products/Small Molecules,Metabolism|||Cytoskeletal Signaling

Key Properties

• CAS Number: 1268273-90-0
• MW: 464.58
• Purity: 100%
• Formula: C₂₄H₂₈N₆O₂S
• SMILES: CN1CCN(CC1)c1ncc(Sc2cccc(NC(=O)CN)c2)c(OCc2ccccc2)n1

Bioactivity

• Target IC50:
  HSP:2.3 μM|Caspase-7:1.9 μM (MOLM13 cells)|Caspase-3:1.9 μM (MOLM13 cells)
• In Vitro:
  Heat shock protein 70 (Hsp70) functions as a molecular chaperone crucial for protein homeostasis, cell signaling, and survival, with its overexpression observed in cancer contributing to chemotherapy resistance. HSP70-IN-1 disrupts this by dose-dependently affecting the formation and stability of the Hsp70-HOP-Hsp90 complex, crucial for cancer cell survival, including altering components of this megacomplex and destabilizing the Hsp70-Hsp90 machinery client, Raf-1. It also inhibits the refolding capability of endogenous and transfected Hsp70 for heat-denatured luciferase in cells, and induces apoptosis in cancer cells by modifying the Hsp70-HOP complex formation and stability, leading to their reduced half-life.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

66973893