Human Clusterin Protein, His Tag

SKU: orb257350

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Description

Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa Nglycosylated disulfidelinked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mR and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Research Area

Disease Biomarkers

Images & Validation

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Item 1 of 1

Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.9 kDa. The protein migrates as 32-40 kDa under reducing (R) condition (SDS-PAGE).

Key Properties

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Expression System	HEK293
Biological Origin	Human
Target	Clusterin
Reactivity	Human
Tag	C-6×His
Expression Region	Asp 23 - Glu 449
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated
MW	50.9 kDa
Purity	95%
Protein Sequence	NP_001822.3

Storage & Handling

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Storage	-20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

Human CLU Protein, His Tag [orb2697227]

Purity:	> 90%, determined by SDS-PAGE
Source:	This protein contains the human CLU isoform long (NP_0018222) (Met 1-Glu 501) was expressed with a C-terminal polyhistidine tag and expressed from HEK293 Cells.

Sizes Available: 50 μg, 500 μg

Human Clusterin Protein, His Tag [orb2696501]
Purity:
> 95% as determined by SDS-PAGE
Sizes Available: 1 mg, 100 μg

Human CLU Protein, His Tag [orb2697739]

Purity:	> 95%, determined by reduced SDS-PAGE
Source:	This protein contains the human CLU isoform long (NP_0018222) (Met 1-Glu 501) was expressed with a C-terminal polyhistidine tag and expressed from HEK293 Cells.

Sizes Available: 1 mg, 100 μg

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Quick Database Links

Gene Symbol

Clusterin

UniProt

P10909

RefSeq (Protein):NP_001822.3

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

Protein	NP_001822.3

Protocol Information

Protein Handling and Storage Guide

Protein Handling Guide

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