Human FGF-23 protein

SKU: orb107724

Description

Fibroblast growth factor-23 (FGF-23) belongs to the large FGF family which has at least 23 members. All FGF family membersare heparin binding growth factors with a core 120 amino acid (a.a.) FGF domain that allows for a common tertiary structure.FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGFreceptors, FGF R1, 2, 3, and 4, exist. FGF-23 is produced by osteocytes and osteoblasts in response to high circulating phosphatelevels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressingcirculating phosphate levels. FGF-23 interaction with renal proximal tubular epithelium decreases the renal resorption ofphosphate by down regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinalabsorption of phosphate.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: FGF-23
• Conjugation: Unconjugated
• MW: 22.5 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSALMIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENGYDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPIPRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDPLGVVRGGRVN THAGGTGPEG CRPFAKFI

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Fibroblast Growth Factor-23 protein

Quick Database Links

Gene Symbol

FGF-23