Human GDNF protein

SKU: orb107727

Description

Glial cell-derived neurotrophic factor, also known as GDNF is a small protein that potently promotes the survival of variousneuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Inaddition, GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 andGDNF family receptor alpha 1. GDNF (monomer) contains seven conserved cysteine residues, one of which (Cys 101) is usedfor inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knotconfiguration.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: GDNF
• Conjugation: Unconjugated
• MW: 15.2 kDa
• Purity: > 97% by SDS-PAGE and HPLC analyses.
• Protein Sequence: MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLNVTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDDDLSFLDDNLV YHILRKHSAK RCGCI

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20mM PB, 500mM NaCl, pH 6.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Glial Cell-derived Neurotrophic Factor protein

Quick Database Links

Gene Symbol

GDNF