Human IL-36 beta (157a.a.) protein

SKU: orb107766

Description

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36F, IL-36=, and IL-36G (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaquesthan in symptomless psoriatic skin or healthy control skin. Furthermore, it can stimulate production of interleukin-6 andinterleukin-8 in synovial fibroblasts, articular chondrocytes and mature adipocytes. Two alternatively spliced transcript variantsencode distinct (164 or 157 residues) protein isoforms that differ in their C-terminal 70 amino acid residues have been reportedand IL-36= isoform 2 is synthesized as a 157 a.a. protein. Specifically, human IL-36= shares low sequence identity with IL-1=, IL-36RA, IL-36F and IL-36G.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-36 beta
• Conjugation: Unconjugated
• MW: 17.7kDa
• Purity: > 97 % by SDS-PAGE and HPLC analyses
• Protein Sequence: MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGNMVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSVSYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Interleukin-36 beta protein

SDS-PAGE analysis of Human IL-36 beta (157a.a.) protein

Quick Database Links

Gene Symbol

IL-36 beta