Human IL-36 gamma (169a.a.) protein

SKU: orb107768

Description

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36F, IL-36G, and IL-36> (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36> is secreted when transfected into 293-T cells and it could constitutepart of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1receptor type I (IL-1R1). Furthermore, IL-36> also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Recombinant human IL-36> is synthesized as a 19 kDa, 169 amino acid (a.a.) protein that contains nosignal sequence, no prosegment and no potential N-linked glycosylation site. Human to mouse, IL-36> shares 53 % a.a. identity.Within the family, IL-36> shares about 25 % ~ 55 % a.a. sequence identity with IL-1RA, IL-1G, IL-36RA, IL-36F, IL-37, IL-36Gand IL-1F10.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-36 gamma
• Conjugation: Unconjugated
• MW: 18.7 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses.
• Protein Sequence: MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDSVTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQPEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Interleukin-36 gamma protein

Quick Database Links

Gene Symbol

IL-36 gamma