Human MANF protein

SKU: orb107776

Description

Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF andARMET, is a secreted protein which belongs to the ARMET family. Recombinant human MANF produced by E. coli is a singlepolypeptide chain containing 183 amino acids (25-182) and having a molecular mass of 20.8kDa. MANF reduces endoplasmicreticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. MANF has been described as a survival factor fordopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. Mature humanMANF is 99%, 98% and 96% a.a. identical to mature rat, mouse and bovine MANF respectively

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: MANF
• Conjugation: Unconjugated
• MW: 18.2 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses.
• Protein Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDAATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKILDDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Mesencephalic Astrocyte-Derived Neurotrophic Factor protein

SDS-PAGE analysis of Human MANF protein

Quick Database Links

Gene Symbol

MANF