Human Neuroserpin protein

SKU: orb107789

Description

Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological targetof neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradationof extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. The neuroprotectiverole of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin inthese mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin,caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy withneuroserpin inclusion bodies (FENIB).

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: Neuroserpin
• Conjugation: Unconjugated
• MW: 44.8kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQGSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQNGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKDLVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIPMMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLATLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEIFIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAVLYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Neuroserpin protein

Quick Database Links

Gene Symbol

Neuroserpin