Human Prolactin Protein

SKU: orb610986

Description

Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Prolactin is secreted when eating, nursing, mating, estrogen treatment and during ovulation. Prolactin's primary role is to promote and maintain lactation but also plays a role in breast cancer development, regulation of reproductive function and immunoregulation

Research Area

,Product Categories/Proteins

Images & Validation

• Application Notes:
  Cytokines And Growth Factors

Key Properties

• Source: E.coli
• Biological Activity: Human Prolactin Antagonist was tested for its biological functionality in-vitro by inducing proliferation of Nb2 cells or Baf/3 cells that were stably transfected with Human Prolactin receptors. Prolactin Antagonist also interacts at 1:1 molar ratio with human prolactin receptor extracellular domain as documented by SEC and SPR (Biacore analysis)
• Target: Prolactin Human Recombinant Antagonist des 1-9, G129R produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids + an additional Ala at n-terminal and having a molecular mass of ~ 22 kDa
• MW: 22kDa
• Purity: Greater than 95.0% as determined by gel filtration analysis
• Protein Sequence: The a.a. sequence of the 1st 6 N-terminal a.a. was found to be Ala-Arg-Ser-Gln-Val-Thr

Storage & Handling

• Storage: Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prolactin should be stored at 4°C between 2-7 days and for future use below -18°C
• Form/Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
• Buffer/Preservatives: The protein was lyophilized from a concentrated (1mg/ml) solution with 0.02% NaHCO3
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mammotropin, Luteotropic hormone, Luteotropin, PRL

Quick Database Links

Gene Symbol

Prolactin Human Recombinant Antagonist des 1-9, G129R produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids + an additional Ala at n-terminal and having a molecular mass of ~ 22 kDa