Human sFasR protein

SKU: orb107710

Description

Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively.Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases thencleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis byacting as a decoy receptor that serves as a sink for FasL

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: sFasR
• Conjugation: Unconjugated
• MW: 17.6 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVNGDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCNSTVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

SDS-PAGE analysis of Human sFasR protein

Quick Database Links

Gene Symbol

sFasR