Detect Range: 15.6 pg/mL-1000 pg/mL. Sensitivity: 10 pg/mL. Gene_name: TFF1. Gene_full_name: Trefoil factor 1. Protein_name: Trefoil factor 1. Sample Type: cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA). Tmb_incubation: 25-30 min. Capture_antibody: monoclonal antibody from mouse. Detection_antibody: polyclonal antibody from goat. Research_category: signal transduction|signaling pathway|nuclear signaling|nuclear hormone receptors|estrogen. Sequence_similarities: Contains 1 P-type (trefoil) domain. Tissue_specificity: Found in stomach with highest levels in theupper gastric mucosal cells (at protein level). Detected in gobletcells of the small and large intestine and rectum smallsubmucosal glands in the esophagus mucous acini of the sublingualgland submucosal glands of the trachea and epithelial cellslining the exocrine pancreatic ducts but not in the remainder ofthe pancreas (at protein level). Scattered expression is detectedin the epithelial cells of the gallbladder and submucosal glandsof the vagina and weak expression is observed in the bronchialgoblet cells of the pseudostratified epithelia in the respiratorysystem (at protein level). Detected in urine (at protein level).Strongly expressed in breast cancer but at low levels in normalmammary tissue. It is regulated by estrogen in MCF-7 cells. Strongexpression found in normal gastric mucosa and in the regenerativetissues surrounding ulcerous lesions of gastrointestinal tract but lower expression found in gastric cancer (at protein level).
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