Human TWEAK Receptor protein

SKU: orb107810

Description

Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamilymember 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14 kD protein, is distantly related to theTNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain butdoes not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes,colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the solubleTWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: TWEAK Receptor
• Conjugation: Unconjugated
• MW: 5.6 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses.
• Protein Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human TNF-related weak inducer of apoptosis receptor protein

Quick Database Links

Gene Symbol

TWEAK Receptor