Human UBC5 protein

SKU: orb107813

Description

Ubiquitin Conjugating Enzyme E2 D3 (UBE2D3)/UBC5C enzymes are human homologs of the yeast UBC4/5 family and playmany important regulatory roles in inflammation and cancer. UbcH5a mediates the degradation of a myriad of short-livedregulatory proteins (such as p53 in the presence of E6/E6-AP or MDM2, c-Fos, p105) and abnormal proteins. UBE2D3 has88% and 89% sequence identity with UbcH5a and UbcH5b respectively.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: UBC5
• Conjugation: Unconjugated
• MW: 17.7 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses.
• Protein Sequence: MHHHHHHAMA LKRINKELSD LARDPPAQCS AGPVGDDMFH WQATIMGPNDSPYQGGVFFL TIHFPTDYPF KPPKVAFTTR IYHPNINSNG SICLDILRSQ WSPALTISKVLLSICSLLCD PNPDDPLVPE IARIYKTDRD KYNRISREWT QKYAM

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, 1mM DTT, pH 7.5.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Ubiquitin Conjugating Enzyme E2 D3/UBC5C, His protein

Quick Database Links

Gene Symbol

UBC5