Hydroxychloroquine sulfate

SKU: orb1310137

Description

Hydroxychloroquine sulfate

Research Area

Product Categories/Products/Small Molecules,Microbiology/Virology|||Autophagy|||DNA Damage/DNA Repair|||Immunology/Inflammation

Key Properties

• CAS Number: 747-36-4
• MW: 433.95
• Purity: 99.88%
• Formula: C₁₈H₂₈ClN₃O₅S
• SMILES: OS(=O)(=O)O.CCN(CCO)CCCC(C)Nc1c2ccc(Cl)cc2ncc1

Bioactivity

• In Vivo:
  The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals.
  Read more...
• In Vitro:
  Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis.
  Read more...
• Cell Research:
  All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference)
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

12947