IGF-1 Antibody / Insulin like Growth Factor 1

SKU: orb749589

Description

This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Product Categories/Products/Antibodies/Primary Antibodies,Epigenetics

Images & Validation

• Tested Applications: FACS, IF, NeA
• Dilution Range: Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 1-4ug/ml,In-vitro neutralization of biological activity of IGF-1 (order BSA/sodium azide-free format)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  Optimal dilution of the IGF-1 antibody should be determined by the researcher.

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG1, kappa
• Clone No.: IGF1/1020
• Immunogen: Full-length recombinant human IGF1 protein was used as the immunogen for the IGF-1 antibody.
• Purity: Protein G affinity chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Store the IGF-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
• Buffer/Preservatives: 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This IGF-1 antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P05019