IKKB Antibody (Center Y609)

SKU: orb106928

Description

Rabbit polyclonal to IKKB. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/NF-kB,Epigenetics,Infectious Diseases,Toll-Like receptor signaling;Apoptosis signaling;Apoptosis;Interleukin signaling;Inflammation mediated by chemokine and cytokine signaling;Chemokine signaling;T cell receptor signaling;T cell activation;B cell receptor signaling;Primary Antibodies;Toll-Like Receptor;Toll receptor signaling;RIG-l-like Receptor;Signal Transduction;Immunology;Cell Biology;Cardiovascular

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Human
• Predicted Reactivity: Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB42186
• Immunogen: Synthetic Peptide
• Target: IKBKB
• Molecular Weight: 86564
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti IKBKB antibody, anti IKKB antibody, anti Inhibitor of nuclear factor kappa-B kinase subunit beta antibody, anti Inhibitor of nuclear factor kappa-B kinase subunit beta antibody, anti I-kappa-B kinase 2 antibody, anti Inhibitor of nuclear factor kappa-B kinase subunit beta antibody, anti Nuclear factor NF-kappa-B inhibitor kinase beta antibody

Quick Database Links

Gene Symbol

IKBKB

UniProt

O14920

RefSeq (Protein):NP_001547.1, NP_001229707.1, NP_001177649.1