IL-31RA Protein, Human, Recombinant (aa 20-519, His)

SKU: orb1959815

Description

Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. IL-31RA Protein, Human, Recombinant (aa 20-519, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q8NI17-1.

Research Area

,Recombinant-Protein

Images & Validation

• Application Notes:
  Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Key Properties

• Expression System: HEK293 Cells
• Biological Origin: Human
• Biological Activity: Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. IL-31RA Protein, Human, Recombinant (aa 20-519, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q8NI17-1.
• Tag: C-His
• Expression Region: Ala20-Glu519
• MW: 58.2 kDa (predicted). Due to glycosylation, the protein migrates to 90-116 kDa based on Tris-Bis PAGE result.
• Purity: 98.00%

Storage & Handling

• Storage: -20°C
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

UniProt

Q8NI17