Illudin S

SKU: orb1818518

Description

Illudin S is a fungal sesquiterpene that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin (Item No. 15007), epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

Key Properties

• CAS Number: [1149-99-1]
• MW: 264.3169
• Formula: C₁₅H₂₀O₄
• SMILES: CC1=C2C(=C[C@@](C)(CO)[C@@H]2O)C(=O)[C@@](C)(C31CC3)O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only