IM156

SKU: orb1298855

Description

IM156

Research Area

Product Categories/Products/Small Molecules,Apoptosis

Key Properties

• CAS Number: 1422365-93-2
• MW: 315.29
• Purity: 100%
• Formula: C₁₃H₁₆F₃N₅O
• SMILES: N(C(NC(=N)N1CCCC1)=N)C2=CC=C(OC(F)(F)F)C=C2

Bioactivity

• In Vivo:
  IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity . IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety . IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory . IM156 markedly increases AMPK activation in the hippocampus of aged mice . Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline.
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• In Vitro:
  IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner . IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) . Western Blot Analysis Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

78092899