Imipenem

SKU: orb1992144

Description

Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study carbapenem non-susceptible infections and Pseudomonas aeruginosa biofilm infections.

Research Area

,Microbiology/Virology

Key Properties

• CAS Number: 64221-86-9
• MW: 299.35
• Purity: ≥98%
• Formula: C₁₂H₁₇N₃O₄S
• SMILES: C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

Bioactivity

• In Vivo:
  In a neutropenic mouse model of biofilm lung infection, the pharmacokinetic parameters of Imipenem (MK0787) were assessed following a single intraperitoneal (IP) administration at various doses (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg). The killing effect was observed to be time-dependent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

104838