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JH-X-119-01

SKU: orb1089899

Description

Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Images & Validation

Key Properties

CAS Number[2227368-54-7]
MW452.474
FormulaC25H20N6O3
SMILESO=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3

Storage & Handling

Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • JH-X-119-01 [orb1298286]

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    2227368-54-7

    452.46

    C25H20N6O3

    25 mg, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 2 mg, 1 ml x 10 mm (in DMSO)
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Protocol Information

JH-X-119-01 (orb1089899)

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100 mg
$ 890.00
250 mg
$ 1,540.00
1 g
$ 2,650.00
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