KChIP2 Antibody / KCNIP2

SKU: orb1826204

Description

In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents control the excitability of neurons and cardiac myocytes. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4Alpha-subunits and are integral components of native Kv4 channel complexes. KChIP family members include KChIP1 expressed in brain, KChIP2 expressed in heart, brain, and lung, and KChIP3 (previously identified as calsenilin) expressed in brain and testis. In rat brain, KChIP1 colocalizes with Kv4.3 in granule cells and KChIP2 colocalizes with Kv4.2 in both neocoritcal and subcortical structures. The KChIPs are members of the recoverin/neuronal calcium sensor-1 subfamily of calcium-binding proteins and show 99% nucleotide homology to DREAM, suggesting that KChIPs may have activity beyond modulation of Kv4 channels.

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG1, kappa
• Clone No.: KCNIP2/7589
• Immunogen: A recombinant partial protein (within amino acids 1-270) from the human protein was used as the immunogen for the KChIP2 antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the KChIP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This KChIP2 antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

Q9NS61