KISS1R Antibody (Center)

SKU: orb106907

Description

Rabbit polyclonal to KISS1R. Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cancer,Neuroscience,Signaling Pathways,Signaling Pathways/GPCR,Epigenetics,Primary Antibodies;Antibody Collections;Neuroscience;Signal Transduction;GPCR Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB40407
• Immunogen: Synthetic Peptide
• Target: KISS1R
• Molecular Weight: 42586
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti KISS1R antibody, anti AXOR12 antibody, anti GPR54 antibody, anti KiSS-1 receptor antibody, anti KiSS-1 receptor antibody, anti G-protein coupled receptor 54 antibody, anti KiSS-1 receptor antibody, anti G-protein coupled receptor OT7T175 antibody, anti KiSS-1 receptor antibody, anti Hypogonadotropin-1 antibody, anti KiSS-1 receptor antibody, anti Kisspeptins receptor antibody, anti KiSS-1 receptor antibody, anti Metastin receptor antibody

Quick Database Links

Gene Symbol

KISS1R

UniProt

Q969F8

RefSeq (Protein):NP_115940.2