KRAS inhibitor-9

SKU: orb1089450

Description

KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [300809-71-6]
• MW: 292.806958913803
• Formula: C₁₃H₉CLN₂S₂
• SMILES: ClC1C([H])=C(C([H])=C([H])C=1SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1)N([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only