L-Glutathione reduced

SKU: orb1309822

Description

L-Glutathione reduced

Research Area

Product Categories/Products/Small Molecules,Apoptosis|||Oxidation-Reduction|||NF-κB|||Metabolism|||Immunology/Inflammation

Key Properties

• CAS Number: 70-18-8
• MW: 307.32
• Purity: 99.97%
• Formula: C₁₀H₁₇N₃O₆S
• SMILES: NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O

Bioactivity

• Target IC50:
  KB-V1 cells:> 20 mM|Glyoxalase I:18 mM (Ki)|KB 3-1 cells:> 20 mM
• In Vivo:
  METHODS: To study in vivo activity, L-Glutathione reduced (100 mg/kg) was administered orally to mice and GSH concentrations were measured in plasma at 30, 45, and 60 min, and in the liver, kidneys, heart, lungs, brain, small intestine, and skin 1 h later. RESULTS: Within 30 min of oral L-Glutathione reduced administration, plasma GSH concentrations increased from 30 µM to 75 µM, consistent with a rapid flow of GSH from the intestinal lumen to the plasma. Under these conditions of GSH sufficiency, GSH concentrations in most tissues did not exceed control values over the same time course, with the exception of lung.
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• In Vitro:
  METHODS: NSCs cells were treated with L-Glutathione reduced (0.5 mM) and sevoflurane (3%) for 24 h. Apoptosis was detected using TUNEL staining. RESULTS: Supplementation with reduced L-Glutathione reduced the effect of sevoflurane on apoptosis of NSCs.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

745