LCS3

SKU: orb1689577

Description

LCS3

Research Area

Product Categories/Products/Small Molecules,Apoptosis|||Oxidation-Reduction

Key Properties

• CAS Number: 109844-92-0
• MW: 266.64
• Purity: 98%
• Formula: C₁₁H₇ClN₂O₄
• SMILES: [O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(Cl)cc1

Bioactivity

• Target IC50:
  GSR:3.3 µM|TXNRD1:3.8 µM|M. tuberculosis:0.098 µM(MIC)
• In Vitro:
  LCS3 (5 nM-10 µM ; 96 h) effectively inhibits lung cancer cell lines, while non-transformed lung cells show no signs of inhibition. LCS3 (3 µM ; 3, 6, and 12 h) induces ROS and NRF2 pathway activation in sensitive lung adenocarcinoma (LUAD) cells. LCS3 (3 µM ; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part through the induction of apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

844044