Lenvatinib mesylate

SKU: orb1298850

Description

Lenvatinib mesylate

Research Area

Product Categories/Products/Small Molecules,Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis

Key Properties

• CAS Number: 857890-39-2
• MW: 522.96
• Purity: 99.79%
• Formula: C₂₂H₂₃ClN₄O₇S
• SMILES: CS(O)(=O)=O.COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O

Bioactivity

• Target IC50:
  PDGFRα:51 nM|PDGFRβ:39 nM|c-Kit:100 nM|FGFR1:46 nM|VEGFR2:4 nM|VEGFR3:5.2 nM|VEGFR1:22 nM
• In Vitro:
  Lenvatinib is a small-molecule tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (KIT), and rearranged during transfection (RET). These receptors are important for tumor angiogenesis, and lenvatinib inhibits tumor angiogenesis by inhibiting function of these receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11237762