Lobaplatin(D-19466)

SKU: orb1089391

Description

Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [135558-11-1]
• MW: 395.313
• Formula: C₉H₁₈N₂O₃PT
• SMILES: CC1[O-][Pt]2(NCC3C(CC3)CN2)[O-]C1=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only