LY 303511 hydrochloride

SKU: orb1302872

Description

LY 303511 hydrochloride

Research Area

Product Categories/Products/Small Molecules,Apoptosis|||PI3K/Akt/mTOR signaling|||Membrane transporter/Ion channel

Key Properties

• CAS Number: 2070014-90-1
• MW: 342.82
• Purity: 97.44%
• Formula: C₁₉H₁₉ClN₂O₂
• SMILES: Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1

Bioactivity

• Target IC50:
  mTOR:
• In Vitro:
  LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

78357796