MDM2 (M) Antibody, Rabbit Polyclonal

SKU: orb67283

Description

Rabbit polyclonal to MDM2.E3 ubiquitin-protein ligase MDM2 is a target gene of the tumor suppressor p53. MDM2 is a nuclearphosphoprotein that binds and inhibits the transcriptional activity of p53 as part of an autoregulatorynegative feedback loop. Overexpression of MDM2 results in excessive inactivation of p53, diminishingits tumor suppressor function. MDM2 has E3 ubiquitin ligase activity, which targets p53 forproteasomal degradation. MDM2 also affects the cell cycle, apoptosis and tumorigenesis throughinteractions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40different alternatively spliced transcript variants of MDM2 have been isolated from both tumor andnormal tissues.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies,Cancer,Infectious Diseases

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of human MDM2
• Molecular Weight: 55
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-MDM2 antibody,anti-E3 ubiquitinprotein ligase MDM2 antibody,anti-Double minute 2 protein antibody,anti-Hdm2 antibody,anti-Oncoprotein Mdm2 antibody,anti-p53binding protein Mdm2 antibody

Quick Database Links

UniProt

Q00987