ML-SA1

SKU: orb1305751

Description

ML-SA1

Research Area

Product Categories/Products/Small Molecules,Membrane transporter/Ion channel

Key Properties

• CAS Number: 332382-54-4
• MW: 362.42
• Purity: 99.28%
• Formula: C₂₂H₂₂N₂O₃
• SMILES: O=C1C=2C=CC=CC2C(=O)N1CC(=O)N3C=4C=CC=CC4C(C)CC3(C)C

Bioactivity

• Target IC50:
  DENV-2:8.3 μM (IC50)|ZIKV:52.99 μM (IC50)
• In Vitro:
  ML-SA1 (25 μM; 0~14 hours; A549 cells) potentially affects the entry of DENV2 into host cells. ML-SA1 (0~200 μM; A549 cells) shows no cytotoxicity at concentrations up to 200 μM. It significantly suppresses DENV2 RNA levels with an IC50 of 8.93 μM. ML-SA1 also reduces ZIKV RNA and protein levels in a dose-dependent manner, with an IC50 of 52.99 μM against ZIKV RNA. As an activator of TRPMLs, ML-SA1 is a potent inhibitor of DENV2 and ZIKV in vitro, promoting lysosomal acidification and protease activity to inhibit viral infection, and can induce autophagy in Huh7 or A549 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

2880983