MMP-9

SKU: orb1945260

Description

Matrix Metalloproteinase-9 (MMP-9), also known as 92-kDa Type IV Collagenase or Gelatinase B, is a member of a family of proteins involved in degradation of the extracellular matrix (ECM). After activation in inflammatory tissues, MMP-9 is produced by neutrophils, macrophages, mast cells, and stromal cells. It has also been reported that the protein may have a crucial role in angiogenesis and neovascularization. As degradation of collagen IV in the basement membrane and ECM promotes tumour progression, including invasion, metastasis, growth, and angiogenesis, MMP-9 is involved in the development of several human malignancies. Overexpression of MMP-9 has been reported in a number of different cancers, including those of the breast and colon, as well as gastric and nasopharyngeal cancers.

Images & Validation

• Tested Applications: IHC
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Monoclonal
• Clone No.: IHC109
• Conjugation: Unconjugated

Storage & Handling

• Storage: Store at 2-8°C. To ensure stability, immediately replace vial back in the refrigerator after each use
• Buffer/Preservatives: Tris Buffer, pH 7.3 - 7.7, with 1% rAlbumin and < 0.1% Sodium Azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only