MMP9 Antibody: APC

SKU: orb149758

Description

Mouse monoclonal to MMP9 (APC). MMP9, otherwise known as matrix metalloproteinase 9, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes like arthritis and metastasis. Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development. One mechanism of MMP regulation is transcriptional. Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein..

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cardiovascular Disease,Epigenetics,Cardiovascular System | Angiogenesis | Cardiovascular Growth Factors | Adhesion / Extracellular Matrix | Matrix Metalloproteinases | Cell Signaling | Extracellular Matrix (ECM) | Enzymes | Cell Signaling | Extracellular Matrix (ECM) | Enzymes | Cancer | Tumor Biomarkers | Tumor Biomarker Enzymes | Cancer | Invasion/microenvironment

Images & Validation

• Tested Applications: ICC, IF, IHC
• Dilution Range: WB (1:1000), ICC/IF (1:100)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml of SMC-396 was sufficient for detection of MMP9 in 20 µg of COS-1 cells (lysate) transfected with human MMP9 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone No.: L51/82 (Formerly sold as S51-82)
• Immunogen: Fusion protein amino acids 1-708 (full length) of rat MMP9
• Target: MMP9
• Molecular Weight: 82kDa
• Conjugation: APC

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP-9 antibody, CLG4B antibody, 82kDa matrix metalloproteinase-9 antibody, collagenease type 4 beta antibody, GELB antibody, Macrophage gelatinase antibody, MANDP2 antibody, Type V collagenase antibody, 92 kDa gelatinase antibody, 92 kDa type IV collagenase antibody, Gelatinase B antibody, MMP9 antibody, Matrix metalloproteinase 9 antibody

Quick Database Links

Gene Symbol

MMP9

UniProt

P50282

NCBI Gene ID

81687

RefSeq (Protein):NP_112317.1