Mouse p21Cip1 Antibody (C-term S148)

SKU: orb107018

Description

Rabbit polyclonal to p21Cip1. May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Product Categories/Products/Antibodies/Primary Antibodies,Epigenetics,Primary Antibodies;Cancer;Cell Biology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Mouse

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB43031
• Immunogen: Synthetic Peptide
• Target: Cdkn1a
• Molecular Weight: 17785
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti Cdkn1a antibody, anti Cip1 antibody, anti Waf1 antibody, anti Cyclin-dependent kinase inhibitor 1 antibody, anti Cyclin-dependent kinase inhibitor 1 antibody, anti CDK-interacting protein 1 antibody, anti Cyclin-dependent kinase inhibitor 1 antibody, anti Melanoma differentiation-associated protein antibody, anti Cyclin-dependent kinase inhibitor 1 antibody, anti p21 antibody

Quick Database Links

Gene Symbol

Cdkn1a

UniProt

P39689

RefSeq (Protein):NP_031695.1, NP_001104569.1