Murine Cardiotrophin-1 protein

SKU: orb107700

Description

Cardiotrophin1(CT1)is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF),oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). CT-1 is a pleiotropic cytokine which is expressed in various tissuesincluding the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung. In addition, CT-1 which induces cardiac myocytehypertrophy in vitro can bind to and activate the ILST/gp130 receptor. Murine CT1encodes a 203 amino acid (a.a.) residueprotein that lacks a hydrophobic signal peptide. Human and murine CT1share 80 % a.a. sequence identity and exhibit crossspeciesactivity.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: Cardiotrophin-1
• Conjugation: Unconjugated
• MW: 18.2 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Protein Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDAATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKILDDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, 3 mM beta -mercaptoethanol, pH 8.5
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Murine Cardiotrophin1 protein

Quick Database Links

Gene Symbol

Cardiotrophin-1