Murine IL-22 protein

SKU: orb107759

Description

IL-22 is belonging to IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Membersof this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Producedby T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 andIL-22. It along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays arole in the coordinated response of both adaptive and innate immune systems. Recombinant mouse interleukin-22 contains 147amino acids and it has approximately 81 % and 92 % amino acid sequence identity with human and rat IL-22.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-22
• Conjugation: Unconjugated
• MW: 16.6 kDa
• Purity: > 96 % by SDS-PAGE and HPLC analyses.
• Protein Sequence: LPVNTRCKLE VSNFQQPYIV NRTFMLAKEA SLADNNTDVR LIGEKLFRGVSAKDQCYLMK QVLNFTLEDV LLPQSDRFQP YMQEVVPFLT KLSNQLSSCHISGDDQNIQK NVRRLKETVK KLGESGEIKA IGELDLLFMS LRNACV

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Murine Interleukin-22 protein

SDS-PAGE analysis of Murine IL-22 protein

Quick Database Links

Gene Symbol

IL-22