Murine IL-36 alpha (160a.a.) protein

SKU: orb107764

Description

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36D, IL-36G, and IL-36H (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36D is mainly found in skin and lymphoid tissues, but also in fetal brain,trachea, stomach and intestine. It is expressed by monocytes, B and T cells. Notably, IL-36 alpha is the only novel IL-1 familymember expressed on T-cells. Recombinant murine interleukin-36 alpha contains 160 amino acids residues which is a single nonglycosylatedpolypeptide. Specifically, mouse IL-36D shares 83 % a.a. sequence identity with rat IL-36D, 54-60 % with human,rabbit, equine and bovine IL-36D.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-36 alpha
• Conjugation: Unconjugated
• MW: 18.0 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Protein Sequence: MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETNRGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFYHKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 5 % trehalose.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Murine Interleukin-36 alpha protein

SDS-PAGE analysis of Murine IL-36 alpha (160a.a.) protein

Quick Database Links

Gene Symbol

IL-36 alpha