MYCN Antibody

SKU: orb1823904

Description

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

Images & Validation

• Tested Applications: ELISA, FACS
• Dilution Range: ELISA (Order BSA-free format for coating),Flow cytometry: 1-2ug/million cells
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone No.: PCRP-MYCN-1A9
• Immunogen: A recombinant human MYCN protein (within amino acids 335-463) was used as the immunogen for the MYCN antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the MYCN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This MYCN antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P04198