NCT-58

SKU: orb1473182

Description

NCT58(NCT 58) is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.

Research Area

Product Categories/Products/Small Molecules

Key Properties

• CAS Number: [2411429-33-7]
• MW: 466.57
• Formula: C₂₇H₃₄N₂O₅
• SMILES: O=C(C1=CC=C2OC(C)(C)C=CC2=C1OC)NC3=CC=C(C(OC)=C3)OCCC4NCCCC4

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only